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    研究员

    靳梦

    时间 :2023-11-01 13:55:58  来源 :  作者 :王加祥

    姓名 : 靳梦
    出生年月 :1985.06.25
    职务 :药物筛选研究室主任
    职称 :研究员
    学历学位 :博士研究生
    研究方向 :神经药理毒理学
    导师类型 :硕士生导师
    简介 :
    2013年毕业于山东大学生命科学学院 ,博士期间赴美国贝勒医学院(Baylor College of Medicine)交流学习两年 ,后作为博士后继续在贝勒医学院工作 ,作为核心成员参与美国国立卫生研究院项目“视神经细胞决定和分化机制研究” ,在神经生物学领域积累了研究经验 。2016年作为山东省科学院高层次引进人才 ,进入山东省科学院生物研究所工作 ,主要从事神经系统疾病模型建立和神经药理毒理学研究 。现任药物筛选研究室主任 ,药物筛选团支部书记 ,济宁医学院兼职教授 。山东省智库专家 ,山东省优秀毕业生指导教师 ,山东省优秀毕业论文指导教师 ,济南市高层次人才 ,济南市优秀科技工作者 ,济南市青年创新先锋 ,山东省化妆品行业协会技术专家委员会专家 ,中国生物化学与分子生物学会工业专业分会委员 。
    主持国家级项目4项 ,主持或作为核心成员参与国际合作 、省市级项目10余项;发表科研论文50余篇 ,其中以第一作者或通讯作者发表SCI论文30余篇(一区论文12篇 ,影响因子大于10论文5篇) ,授权发明专利9项 。Frontiers in Neuroscience专题编辑 ,获“山东省高等学校科学技术奖” 、“山东省海洋科技创新奖”等科研奖励6项 。
    培养学生情况 :
    积极开展本科生实践教学和研究生培养 ,获得济宁医学院“实践教学名师奖” ,指导学生获“山东省研究生优秀成果奖”“山东省优秀硕士学位论文” 。近5年培养硕士研究生20余人 ,3名学生获得国家奖学金 、2名学生获得山东省优秀毕业生称号 、多名学生获得校百优学生 、校级奖学金等 。
     
     
    近5年承担项目情况 、成果奖励情况 、授权专利 、代表性论文等 :
    项目 :
    (1)国家科学技术部 ,一带一路”创新人才交流外国专家项目 ,“抗神经系统疾病活性物质***” ,2021.01-2022.12 ,30万 ,结题 ,主持;
    (2)济南市科学技术局 ,济南市“新高校20条”高校院所科研带头人工作室 ,“抗癫痫药物高效筛选技术研发及应用” ,2022.01-2024.12 ,20万 ,在研 ,主持;
    (3)国家科学技术部 ,国家高端外国专家引进计划 ,“基于冠状病毒关键抗原***” ,2020.01-2021.01 ,50万元 ,结题 ,主持;
    (4)国家自然科学基金委员会 ,国家自然科学基金青年基金 ,“EYA2通过与PAX6相互作用调控乳腺癌侵袭和转移的机制研究” ,2019.01-2021.12 ,21万元 ,结题 ,主持;
    (5)齐鲁工业大学(山东省科学院) ,校(院)科教产融合创新试点工程 ,“基于斑马鱼模型的早期活性筛选与安全性评价关键技术研究” ,2020.01-2021.12 ,481.2万元 ,结题 ,子课题负责人;
    (6)齐鲁工业大学(山东省科学院) ,科教产融合试点工程基础研究类项目 ,“高通量筛选体系导向的抗癫痫活性化合物筛选分析和作用机制研究” ,2022.01-2023.12 ,30万元 ,在研 ,主持;
    (7)齐鲁工业大学(山东省科学院) ,科教产融合试点工程重大创新专项 ,“生物智能制造关键技术及应用示范” ,2022.08-2024.08 ,1200万元 ,在研 ,子课题负责人 。
    成果奖励 :
    (1)2023.05 ,第十八届“挑战杯”山东省大学生课外学术科技作品竞赛特等奖(指导教师 ,1/2);
    (2)2022.12 ,山东省优秀硕士学位论文(指导教师 ,1/1);
    (3)2021.11 ,山东省海洋科技创新奖基础类二等奖(1/9);
    (4)2021.10 ,山东省研究生优秀成果奖三等奖(指导教师 ,1/2);
    (5)2021.10 ,唐山市自然科学优秀论文奖三等奖(5/6);
    (6)2021.07 ,齐鲁工业大学(山东省科学院)高质量学术成果奖(自然科学类)一等奖(1/5);
    (7)2021.07 ,山东省科学院生物研究所博科科技创新奖一等奖(1/1);
    (8)2020.12 ,年山东省高等学校优秀科研成果奖一等奖(4/12) 。
    授权专利 :
    (1)一种提神醒脑药物筛选的方法和车叶草苷在提神醒脑方面中的应用 ,ZL202210986368.4 ,2023.05.09(1/7);
    (2)一种蛇毒凝血酶原激活物及基于蛇毒凝血酶原活无的快速止血材料 ,ZL202010409822.0 ,2021.05.14(1/7);
    (3)一种凝血酶原激活因子及含凝血酶原激活因子的快速止血材料 ,ZL202010434949.8 ,2021.05.11(2/7);
    (4)一种基于聚合氨基酸的多组分创面修复止血敷料及其应用 ,ZL202111313043.1 ,2022.06.21(3/11);
    (5)一种交联壳聚糖微球及其在创面止血修复材料中的应用 ,ZL202111316731.3 ,2022.06.21(3/11);
    (6)一种基于双香豆素衍生物的过氧化亚硝酸盐荧光探针 、制备方法与应用 ,ZL201911289368.3 ,2020.12.01(3/6);
    代表性论文 :
    1.    Wang LZ#, Mou L#, Guan SB, Wang CS, Sik A, Stoika R, Liu KC, Jin M*: Isoliquiritigenin induces neurodevelopmental-toxicity and anxiety-like behavior in zebrafish larvae. Comp Biochem Phys C 2023, 266.
    2.    Shi R#, Gao D#, Stoika R, Liu K, Sik A, Jin M*: Potential implications of polyphenolic compounds in neurodegenerative diseases. Critical reviews in food science and nutrition 2022:1-24.
    3.    Song Y, Liu S, Jiang X, Ren Q, Deng H, Paudel YN, Wang B, Liu K, Jin M*: Benzoresorcinol induces developmental neurotoxicity and injures exploratory, learning and memorizing abilities in zebrafish. The Science of the total environment 2022, 834:155268.
    4.    Ren Q#, Jiang X#, Zhang S#, Gao X, Paudel YN, Zhang P, Wang R, Liu K, Jin M*: Neuroprotective effect of YIAEDAER peptide against Parkinson's disease like pathology in zebrafish. Biomedecine & pharmacotherapie 2022, 147:112629.
    5.    Ren Q#, Jiang X#, Paudel YN, Gao X, Gao D, Zhang P, Sheng W, Shang X, Liu K, Zhang X*, Jin M*: Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish. Journal of ethnopharmacology 2022, 292:115234.
    6.    Li X#, Gao D#, Paudel YN, Li X, Zheng M, Liu G, Ma Y, Chu L, He F*, Jin M*: Anti-Parkinson's Disease Activity of Sanghuangprous vaninii Extracts in the MPTP-Induced Zebrafish Model. ACS chemical neuroscience 2022, 13(3):330-339.
    7.    Wang R#, Ren Q#, Gao D#, Paudel YN, Li X, Wang L, Zhang P, Wang B, Shang X*, Jin M*: Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis. Journal of ethnopharmacology 2022, 289:115018.
    8.    Jin M#, Li N#, Sheng W, Ji X, Liang X*, Kong B, Yin P, Li Y, Zhang X, Liu K*: Toxicity of different zinc oxide nanomaterials and dose-dependent onset and development of Parkinson's disease-like symptoms induced by zinc oxide nanorods. Environment international 2021, 146:106179.
    9.    Ren Q#, Gao D#, Mou L#, Zhang S, Zhang M, Li N, Sik A, Jin M*, Liu K*: Anticonvulsant activity of melatonin and its success in ameliorating epileptic comorbidity-like symptoms in zebrafish. European journal of pharmacology 2021, 912:174589.
    10.   Dang J#, Paudel YN#, Yang X#, Ren Q, Zhang S, Ji X, Liu K, Jin M*: Schaftoside Suppresses Pentylenetetrazol-Induced Seizures in Zebrafish via Suppressing Apoptosis, Modulating Inflammation, and Oxidative Stress. ACS chemical neuroscience 2021, 12(13):2542-2552.
    11.   Ji X#, Wang B#, Paudel YN#, Li Z, Zhang S, Mou L, Liu K, Jin M*: Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy. Frontiers in molecular biosciences 2021, 8:655549.
    12.   Jin M, Dang J, Paudel YN, Wang X, Wang B, Wang L, Li P, Sun C, Liu K*: The possible hormetic effects of fluorene-9-bisphenol on regulating hypothalamic-pituitary-thyroid axis in zebrafish. The Science of the total environment 2021, 776:145963.
    13.   Li X, Dang J, Li Y, Wang L, Li N, Liu K, Jin M*: Developmental neurotoxicity fingerprint of silica nanoparticles at environmentally relevant level on larval zebrafish using a neurobehavioral-phenomics-based biological warning method. The Science of the total environment 2021, 752:141878.
    14.   Wang L#, Sheng W#, Tan Z, Ren Q, Wang R, Stoika R, Liu X, Liu K, Shang X*, Jin M*: Treatment of Parkinson's disease in Zebrafish model with a berberine derivative capable of crossing blood brain barrier, targeting mitochondria, and convenient for bioimaging experiments. Comparative biochemistry and physiology Toxicology & pharmacology : CBP 2021, 249:109151.
    15.   Jin M, Ji X, Stoika R, Liu K, Wang L*, Song Y: Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study. Bioorganic chemistry 2020, 101:104021.
    16.   Jin M, Gao D, Wang R, Sik A, Liu K*: Possible involvement of TGFbeta-SMAD-mediated epithelialmesenchymal transition in prometastatic property of PAX6. Oncology reports 2020, 44(2):555-564.
    17.   Jin M#,*, Zhang B#, Sun Y#, Zhang S, Li X, Sik A, Bai Y*, Zheng X*, Liu K*: Involvement of peroxisome proliferator-activated receptor gamma in anticonvulsant activity of alpha-asaronol against pentylenetetrazole-induced seizures in zebrafish. Neuropharmacology 2020, 162:107760.
    18.   Zhang S, Yu Z, Xia J, Zhang X, Liu K, Sik A, Jin M*: Anti-Parkinson's disease activity of phenolic acids from Eucommia ulmoides Oliver leaf extracts and their autophagy activation mechanism. Food & function 2020, 11(2):1425-1440.
    19.   Zhang B#, Wang L#, Ji X#, Zhang S, Sik A, Liu K, Jin M*: Anti-Inflammation Associated Protective Mechanism of Berberine and its Derivatives on Attenuating Pentylenetetrazole-Induced Seizures in Zebrafish. Journal of neuroimmune pharmacology 2020, 15(2):309-325.
    20.   Shang X#, Ji X#, Dang J, Wang L, Sun C, Liu K, Sik A, Jin M*: alpha-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish. Toxicology letters 2020, 324:1-11.
    21.   Shang X*, You C, Li X, Yuan L, Jin M*, Zhang X*: Involvement of 5-HT2 serotonin receptors in cognitive defects induced by aristolochic acid I in mice. Toxicology 2020, 447:152624.
    22.   Li X, Ji X, Wang R, Zhao J, Dang J, Gao Y, Jin M*: Zebrafish behavioral phenomics employed for characterizing behavioral neurotoxicity caused by silica nanoparticles. Chemosphere 2020, 240:124937.
    23.   Jin M, Xiao Z, Zhang S, Men X, Li X, Zhang B, Zhou T, Hsiao CD, Liu K*: Possible involvement of Fas/FasL-dependent apoptotic pathway in alpha-bisabolol induced cardiotoxicity in zebrafish embryos. Chemosphere 2019, 219:557-566.
    24.   Jin M#, Ji X#, Zhang B, Sheng W, Wang R, Liu K*: Synergistic effects of Pb and repeated heat pulse on developmental neurotoxicity in zebrafish. Ecotoxicology and environmental safety 2019, 172:460-470.
    25.   Li X, Kong H, Ji X, Gao Y, Jin M*: Zebrafish behavioral phenomics applied for phenotyping aquatic neurotoxicity induced by lead contaminants of environmentally relevant level. Chemosphere 2019, 224:445-454.
    26.   Li X, Zhang B, Li N, Ji X, Liu K*, Jin M*: Zebrafish neurobehavioral phenomics applied as the behavioral warning methods for fingerprinting endocrine disrupting effect by lead exposure at environmentally relevant level. Chemosphere 2019, 231:315-325.
    27.   Jin M, Sheng W, Han L, He Q, Ji X, Liu K*: Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. Fish & shellfish immunology 2018, 83:26-36.
    28.   Jin M, He Q, Zhang S, Cui Y, Han L*, Liu K*: Gastrodin Suppresses Pentylenetetrazole-Induced Seizures Progression by Modulating Oxidative Stress in Zebrafish. Neurochemical research 2018, 43(4):904-917.
     
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